A rapidly-activating delayed rectifier K current, IKr, regulates pacemaker activity in adult mouse sinoatrial node cells Short title: IKr regulates mouse cardiac pacemaker activity
نویسندگان
چکیده
Department of Physiology and Biophysics, University of Calgary, Health Sciences Centre, 3330 Hospital Drive, N.W., Calgary, Alberta, Canada T2N 4N1 *Laboratoire de Genomique Fonctionnelle CNRS UPR 2580 and Institut de Genetique Humaine, CNRS UPR 1142 141 rue de la Cardonille, 34396 Montpellier Cedex 5, France Department of Internal Medicine, Karl-Franzens-University Hospital, Auenbruggerplatz 15, 8036 Graz, Austria Current address: Department of Bioengineering, University of California San Diego, La Jolla, CA, USA, 92093-0412
منابع مشابه
A rapidly activating delayed rectifier K+ current regulates pacemaker activity in adult mouse sinoatrial node cells.
We have investigated the physiological role of the "rapidly activating" delayed rectifier K+ current (IKr) in pacemaker activity in isolated sinoatrial node (SAN) myocytes and the expression of mouse ether-a-go-go (mERG) genes in the adult mouse SAN. In isolated, voltage-clamped SAN cells, outward currents evoked by depolarizing steps (greater than -40 mV) were strongly inhibited by the class I...
متن کاملRoles of L-type Ca and delayed-rectifier K currents in sinoatrial node pacemaking: insights from stability and bifurcation analyses of a mathematical model
Kurata, Yasutaka, Ichiro Hisatome, Sunao Imanishi, and Toshishige Shibamoto. Roles of L-type Ca2 and delayed-rectifier K currents in sinoatrial node pacemaking: insights from stability and bifurcation analyses of a mathematical model. Am J Physiol Heart Circ Physiol 285: H2804–H2819, 2003. First published August 14, 2003; 10.1152/ajpheart.01050.2002.—To elucidate the dynamical mechanisms of the...
متن کاملA mechanistic link between an inherited and an acquird cardiac arrthytmia: HERG encodes the IKr potassium channel
Mutations in HERG cause an inherited cardiac arrhythmia, long QT syndrome (LQT). To define the function of HERG, we expressed the protein in Xenopus oocytes. The biophysical properties of expressed HERG are nearly identical to the rapidly activating delayed rectifier K+ current (IKr) in cardiac myocytes. HERG current is K+ selective, declines with depolarizations above 0 mV, is activated by ext...
متن کاملDirect negative chronotropic action of desflurane on sinoatrial node pacemaker activity in the guinea pig heart.
BACKGROUND Desflurane inhalation is associated with sympathetic activation and concomitant increase in heart rate in humans and experimental animals. There is, however, little information concerning the direct effects of desflurane on electrical activity of sinoatrial node pacemaker cells that determines the intrinsic heart rate. METHODS Whole-cell patch-clamp experiments were conducted on gu...
متن کاملElectrophysiological properties of myocytes isolated from the mouse atrioventricular node: Lâ•’type ICa, IKr, If, and Naâ•’Ca exchange
The atrioventricular node (AVN) is a key component of the cardiac pacemaker-conduction system. This study investigated the electrophysiology of cells isolated from the AVN region of adult mouse hearts, and compared murine ionic current magnitude with that of cells from the more extensively studied rabbit AVN. Whole-cell patch-clamp recordings of ionic currents, and perforated-patch recordings o...
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تاریخ انتشار 2003